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Anabolic steroids

Drostanolone (Masteron): a former breast-cancer drug with almost no modern data

Compound: Drostanolone propionateEvidence base: Very limitedUpdated: 2026-10-02Last reviewed: September 2026By: APEDRA editorial team

Drostanolone was historically used in advanced breast cancer. There are no modern controlled trials of its body-composition effects, and claims about 'hardening' or cosmetic benefits rest on anecdote rather than measurement.

Key points

  • Historical oncology use predates modern trial reporting standards.
  • As an androgen, suppression of the reproductive axis and lipid changes are expected class effects.
  • Virilising effects in women are well described for androgens in this class.
  • Products sold online under this name have not been independently verified; label identity and concentration cannot be assumed.

What the literature shows

Clinical reports from the oncology era describe drostanolone as an androgenic treatment for metastatic breast cancer; outcomes were measured as tumour response, not muscle or performance.

Doping-control literature lists drostanolone among the androgens commonly detected in sport, which reflects use, not safety or effectiveness.

What remains unknown

  • No contemporary human data on cardiovascular, hepatic or psychiatric outcomes specific to drostanolone.
  • Interaction effects when combined with other androgens are unknown.

Safety and monitoring implications

  • Women face a risk of irreversible voice deepening and other virilising changes.
  • Expect reproductive suppression; persistent symptoms after stopping deserve endocrine assessment.

Cited literature

  1. 1.Kicman AT. (2008). Pharmacology of anabolic steroids. British Journal of Pharmacology. Find on PubMed
  2. 2.Pope HG Jr, Wood RI, Rogol A, et al. (2014). Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement. Endocrine Reviews. Find on PubMed

Community reports

Anecdotal — not scientific evidence

Lived experience is valuable context and often surfaces problems before the literature does. It is also uncontrolled, unverified and subject to bias, so it never overrides published findings here.

Editorial evidence status

Mixed

Community discussion of this compound is widespread, but no independently verified reports were available for this analysis. Anecdotes have not been invented or treated as clinical evidence.

Buying Drostanolone propionate in Australia: what to check first

APEDRA does not sell Drostanolone propionate or any other product, and takes no commission from suppliers. If you are researching where to buy it, the biggest practical risk is not the compound itself but what is actually in the bottle: under-dosing, substitution with a different compound, and contamination are all documented in independent testing of online research chemicals.

  • Ask for a batch-specific third-party lab report (HPLC/mass spectrometry), not a generic certificate.
  • Check independent review platforms, not only reviews hosted on the seller's own site.
  • Read the shipping, returns and refund policies before ordering.
  • Be wary of prices far below the market or exaggerated results claims.

Compare Australian vendors independently · how we assess suppliers

Terms used here are defined in our glossary, and the evidence-grading scale explains what this analysis's grade means. If you believe something here is wrong, tell us.

This analysis is educational. It is not medical advice, a dosing recommendation, or an endorsement of use. Speak with a qualified medical practitioner about your circumstances.